A 46 years old male was suffering from inadequate bowel evacuation for many years. He was passing mucus mixed stool almost 10 times a day for the last 18 years. He also suffered from less appetite, fatty liver, raised PSA, SGOT & SGPT levels and frequent urination. Renowned gastroenterologists performed different investigations to diagnose his disease and he was diagnosed as having IBS. Allopathic medicines gave symptomatic relief that too only for a very short period of time after which all the symptoms recurred.After thorough examination he was diagnosed with having Grahani Roga (Pitta type) and he was administered Panchakarma treatment and internal Ayurveda herbal health supplements.Incidence Irritable bowel syndrome (IBS) is the most common functional gastrointestinal (GI) disorder with worldwide prevalence rates ranging from 9–23%. The age distribution is very broad, but 40% of the patients are aged between 35 and 50 years. Symptoms begin before the age of 35 in 50% of patients. Only between 30-70% of “patients” suffering from IBS symptoms are “consulters” with symptoms experienced severe enough to trigger a physician visit. Significant proportions – 35% to 40% – of individuals who report IBS in the community are male. Approximately 60% to 65% of individuals who report IBS in the community are female. Grahani roga – IBS: A Clinical CorrelationThe pathogenesis of IBS will be confirmed by observing the etiological factors, symptoms, Upashaya (Relieving factors) & complications of the IBS.Etiological factorsPertaining to Ahara • Unwholesome food (Heavy, Coarse food)• Irregular eatingPertaining to Vihara• Suppression of natural urges• Desha-Kala Vaishamya (Environmental and Seasonal variations)• Mental Stress (in 70 to 90% of Patients)• Both anxiety & depression can impact on the perception of symptoms.It has rightly been said by Vagbhata that all the ailments of the body, especially diseases of alimentary tract arise due to the malfunction of Agni. IBS is also one such disease which occurs due to the ingestion of unwholesome diet causing disturbances in Agni. Psychological factors like Kama (Lust), Krodha (Anger), Shoka (Grief) etc. leads to Agni dusti (improper function of digestive fire, collectively it is called Grahani Dosha). A careful review of the clinical picture of various GIT diseases, described in Ayurveda reveals that some of the disorders definitely have some clinical symptoms which are also observed in the patients of IBS e.g. Vataja & Kaphaja Atisara, Sangraha Grahani, Pravahika, Pakvashaya gata Vata. But if we take a look into the pathogenesis of all these diseases, there is a stage of Grahani Dosha. So we may consider IBS as Grahani Dosha. Life is the complex union of Sattva, Atma, and Sharira. Thus, mind, body and soul influence each other. Charaka has greatly emphasized the need for a healthy mind for the maintenance of good physical health. Descriptions like Acharaya Rasayana and Sadvritta are available in the literature to illustrate the psychosomatic approach for prevention and treatment of a disease. Irritable Bowel Syndrome (IBS) is one of the most common conditions encountered in clinical practice but one of the least well understood. Irritable bowel syndrome is common with a wide variety of presentations having gastrointestinal motility disorder that place a substantial burden on patients and society. Symptoms of this disorder are chronic, sometimes severe, and often respond poorly to treatment with traditional approaches, resulting in reduced quality of life. Because structural, physical, or biochemical markers cannot be used to identify either disorder, diagnosis is symptom-based. In the absence of alarming features suggestive of organic disease or secondary causes of symptoms, these disorders can be positively and confidently diagnosed. Until, recently, many physicians did not consider IBS to be a disease at all; they viewed it as nothing more than a somatic manifestation of psychological stress. Stress shows no discrimination on the basis of either age, sex or occupation it strikes everyone and unfortunately more & more young people buckle down under it. IBS according to Ayurveda can be considered as a disorder where there is a derangement of Vata in Pakvashaya (intestine) especially of Apana Vayu leading to Symptoms of pain in abdomen & altered bowel habits. Mandagni (Decreased Digestive fire) leads to Vitiation of Doshas. The emotions like Krodha (anger), Shoka (grief), Bhaya (fear) etc. cause vitiation of Vata. Thus, disturbance in mental health directly affects the gastrointestinal tract.Many formulations are explained in classical texts having its efficacy on gastrointestinal disorder. The line of treatment of Grahani mentioned in Ayurveda texts is same as Atisara (Diarrhea) and Ajirna (Indigestion), that is the use of Grahi (Bowel binding), Dipana (Appetizing)) and Pachana (Digestive) herbs and foods. Also Piccha basti is explained as one of the treatment methods in Atisara. Piccha basti cures excess bowel movements and duodenal disorders. Medhya rasayana group of drugs described in ancient literature is the molecular nutrients for the brain, and is claimed to relieve mental fatigue, anxiety, and stress at psychological and neuroendocrine levels. Since IBS is a psychosomatic disorder, Medhya Rasayana added to the principal therapy proves effective in all cases of IBS.There is remarkable improvement visibly in IBS cases with Ayurvedic treatments. One case study is discussed below.IBS in the WorldGrahani Roga or IBS, the commonest clinical manifestation of gastro-intestinal pathology, is emerging as a lifestyle disorder and is encountered frequently in day to day practice. Patients generally approach the Ayurvedic system for the therapy only when they get exhausted from the incomplete treatments and unwanted complications from conventional medicine, by when the disease condition almost gets intractable. Ayurvedic texts explain Grahani as a Gastrointestinal Disorder caused due to the impairment of the Jatharagni (Digestive fire). Irritable bowel syndrome (IBS) has clinical resemblance with that of Grahani, like alternate constipation and diarrhea (Muhurbaddha / Muhurdrava), mucus mixed stools (Sasleshma Mala Pravrtti), etc.