Dao Supplement Health Benefits & Precautions

Table of Contents

What is DAO (Diamine oxidase)?

Diamine oxidase (DAO) is a digestive enzyme produced by your kidneys, thymus, and the intestinal lining of your digestive tract. This enzyme and nutrient supplement is often utilized to treat histamine intolerance symptoms. Supplementing with DAO might have some advantages, but research is limited. This post reviews DAO nutritional supplements, including their benefits and safety.

Various factors may contribute to diminished DAO action or overproduction of histamine, such as genetic mutations, intestinal bacterial overgrowth, alcohol use, certain medications, and eating massive quantities of histamine-containing foods.

Histamine is a naturally occurring compound that helps modulate certain functions of your digestive, nervous, and immune systems. You can also ingest histamine through your diet. It naturally occurs in certain foods, especially the aged, treated, or fermented foods, such as wine, cheese, pickles, and smoked meats. DAO retains histamine levels in a healthy range to prevent uncomfortable histamine-induced symptoms. DAO’s principal purpose is to break down excess histamine in your body. If you have ever experienced an allergic reaction, you are probably knowledgeable about common symptoms associated with elevated histamine levels, such as headaches, nasal congestion, itchy skin, and coughing

Diamine oxidase can relieve uncomfortable symptoms like nasal congestion, itchy skin, headaches, and coughing. Histamine intolerance is a medical condition that occurs because of elevated histamine levels. Among the supposed causes of histamine intolerance is DAO lack.  When your DAO levels are too low, it is hard for the body to metabolize and excrete excess histamine efficiently. Because of this, histamine levels rise, resulting in various physical symptoms. Indicators of histamine intolerance often resemble those of an allergic response. 

Natural herbs for skin care

Histamine intolerance & digestive issues

Migraines and Headaches

Histamine Intolerance is common. Experts find that the source of lots of health challenges in people prove to be histamine intolerance. After laboratory testing rules out autoimmunity and other more significant issues, they often realize that the mysterious origin of an individual’s neuropathy, headaches, sinus problems, and much more all boils down to the sometimes tough to detect an issue.

Diet and the foods you eat can also aggravate your symptoms. If you realize that certain foods appear to be triggering headaches, neuropathy, sinus problems, dizziness, flushing in the face, and more, then histamine intolerance might be the culprit. Foods and beverages like black and green tea, many citruses, red wine, avocados, and legumes that aren’t too fresh such as aged steaks, can all be high in histamine itself. They may also block the action of DAO, the enzyme that’s responsible for breaking down histamine from the gut.

A research study in 100 individuals with previously diagnosed DAO deficiency observed that participants who supplemented daily with DAO experienced a 23 percent decrease in the duration of migraine attacks, in contrast to the placebo group.

In another study in 14 individuals with histamine intolerance and symptoms, including abdominal pain, bloating, or nausea, 93 percent of participants, reported a resolution of at least one digestive sign after taking 4.2 milligrams DAO twice per day.

DAO supplements health benefits

 If you believe you are experiencing histamine intolerance, consult with a professional health care provider to thoroughly investigate the causes of your symptoms before trying to diagnose or treat yourself. Histamine intolerance can be tricky to diagnose, as its symptoms are ambiguous and resemble other medical problems. Assess your vitamin levels using an at-home micronutrient test.

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DAO Supplements Benefits: DAO supplements can treat histamine intolerance in various ways. Early research indicates that DAO supplements can alleviate specific symptoms of histamine intolerance, including headaches, skin rashes, and digestive distress.

Dietary histamine intolerance

If you have been advised that you have an intolerance to dietary histamine or have found that fact out on your own, following a deficient histamine diet can help you manage uncomfortable symptoms. Although one of the principal functions of histamine is associated with allergic reactions, it’s also an important neurotransmitter and resistant messenger molecule. Histamine is stored in mast cells and then released when these cells are activated.

Though histamine is small compared to other biological molecules, it has a significant role in the body. It’s known to participate in over 23 different physiological functions, and it is all thanks to histamine’s flexible chemical binding arrangement. When histamine is present, it’s broken down by specific enzymes. The central nervous system is metabolized by histamine N-methyltransferase (HNMT), while in the digestive tract, it’s broken down by diamine oxidase (DAO). Histamine becomes a problem once we have metabolic disturbances, which don’t allow us to metabolize histamine properly, especially for DAO efficiently. If DAO is inhibited, histamine will collect in the bloodstream and would lead to intolerance.

DAO deficiency can be due to genetic factors (primary deficiency) when specific sequence variations (polymorphisms) in the DAO gene result in a considerably reduced DAO receptor action. People with a DAO gene mutation can have a tendency towards high histamine.

Diet & foods for DAO

The DAO enzyme depends on vitamin B6, B12, iron, copper, and vitamin C, thus increasing these chemicals’ intake. Copper and Vitamin C are crucial elements of this DAO enzyme, and B6 is an integral cofactor that empowers DAO to degrade histamine. Zinc is critical, too, as zinc prevents intestinal copper absorption.

DAO vitamins and minerals

No matter our consumption of different supplements, drugs, or medications, the most important thing, in the end, is how we act with our body and what we’re consuming to make it better. Going on a low-histamine diet may be a good first step. Some foods naturally have more histamine content, while others collect histamines while they age. Fermented and dried foods typically have high levels of histamines. A minimal histamine diet has to be concentrated around getting foods at their peak level of freshness.

Low Histamine Foods:

Freshly Cooked Meat & Poultry

Freshly Caught Fish

Extra Virgin Olive Oil

Gluten-Free Grains: brown rice & quinoa

Fresh Fruits (except citrus, avocado, tomato, pineapple, & bananas)

Pasture-Raised Eggs

Rice milk, Almond milk

Coconut oil

Grass-fed Butter/Ghee

Fresh Vegetables (except eggplant)

Leafy herbs

Herbal teas

Foods High in Histamines: Here’s a list of top histamine foods:

Fermented alcoholic drinks, particularly wine, champagne, and beer

Fermented foods: sauerkraut, vinegar, soy sauce, kefir, yogurt, kombucha, etc.

Dried fruit: apricots, prunes, dates, figs, raisins

Most citrus fruits

Aged cheese such as goat cheese

Nuts: walnuts, cashews, and peanuts

Vegetables: avocados, eggplant, spinach, and tomatoes

Vinegar-containing foods: pickles, mayonnaise, olives

Histamine-Releasing Foods: These foods don’t automatically contain histamine, but they block the activity of DAO, and therefore, they potentiate the effects of elevated histamines.






Cow’s Milk




Precautions & side effects

Low levels of DAO can cause histamine levels to rise and potentially lead to histamine sensitivity, chronic inflammation, or allergic symptoms such as hives, swelling, low blood pressure, difficulty breathing, and severe diarrhea. High levels of mast cell mediators are released during those episodes. The only way to effect a remedy for histamine intolerance is to discover the excess histamine’s origin and cure that. If the underlying cause is shown to be a deficiency of DAO enzyme, a histamine-restricted diet, or supplemental DAO may help the person to stay relatively symptom-free. Taking DAO nutritional supplements won’t heal histamine intolerance. The supplement will reduce histamine amount going into the body and minimize histamine’s overall amount within the body. 

This effect might be sufficient to decrease the amount to below the individual’s limitation of tolerance and provide symptomatic relief. Whenever the person’s total amount of histamine from external and internal resources exceeds their limit of tolerance in the foreseeable future, symptoms will develop. There are many reasons one can have a surplus of histamine in the body. Consult your doctor before jumping to the conclusion that DAO deficiency is the reason.

The DAO receptor itself doesn’t create any harmful effects as DAO isn’t absorbed into the body. Any adverse reactions to the supplement will be on account of the supplement’s extra ingredients, which were absorbed into the body. Take time to read the ingredients on the product label. Avoid supplements that include anything to which you know you’re intolerant or allergic.


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