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Obesity research studies for holistic treatments

Around the world over thousands of years, patients have received root-cause holistic treatment for their diseases with personalized
treatment, diet and lifestyle modification recommendations. Read the inspiring true stories of practitioners who heal people and who recovered
from their problems after obesity treatment at their clinics. Many have been generous to share their knowledge and experience for the benefit
of other holistic experts and patients alike. Many practitioners share their Case Studies and the healing powers of obesity and related therapies
as they heal people who benefited from our expertise.

/ title=”Concept Of Balanced Ahara In Obesity”>
Concept Of Balanced Ahara In Obesity

May 2018

Obesity is becoming a global epidemic. In urban India 30% men and 50% women are overweight (WHO). Obesity is the basic cause for hypertension, cardiovascular diseases and diabetes mellitus. In next few years India is going to be the capital of hypertension and diabetes. In Ayurveda the concept of Balanced Ahar dates back more than 5000 years. The food which passes through the process of aharan is called ahar. In Ayurveda, foods are classified into six tastes–sweet, sour, salty, bitter, pungent and astringent. Inclusion of all these tastes in the food will give balancing effect to the ahar and will minimise craving for food. Balanced ahar in modern science includes fruits, vegetables, whole grains, fat-free milk products, lean meats, poultry, fish, bean, eggs, and nuts. It should be low in saturated fats, trans fats, cholesterol, salt (sodium), and added sugars. According to Ayurveda, the main causative factor for obesity is Atisnigdha Ahaar, Madhur Ahaar and Avyayam. Such ahar, if replaced with katu, tikta, kashaya and ruksha gunatmak ahaar together with some relevant exercise, excess medodhatu deposited in the body will be reduced. Obese person should eat pulses like Green gram, Red gram, Bengal gram, horse gram & lentil, cereals like Yava, Jawar, Bajra, Jeerna Shali. He should drink luke warm water along with honey. One should eat all green leafy vegetables, gray coloured smll fishes and drink buttermilk. One should avoid madhur rasatmak ahaar, pulses like black gram, cereals like wheat, and new rice of shali variety. Meat, fishes, fatty milk products, sugar, sugarcane and all types of sweets. Obesity occurs neither due to single cause nor it has single solution. Its treatment is combined effect of medicine, balanced diet, behavioural changes and exercise.

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/ title=”Purple Sweet Potato Leaf Extract Induces Apoptosis and Reduces Inflammatory Adipokine Expression in 3T3-L1 Differentiated Adipocytes.”>
Purple Sweet Potato Leaf Extract Induces Apoptosis and Reduces Inflammatory Adipokine Expression in 3T3-L1 Differentiated Adipocytes.

December 2014

Background. Purple sweet potato leaves (PSPL) are widely grown and are considered a healthy vegetable in Taiwan. PSPL contain a high content of flavonoids, and the boiling water-extracted PSPL (PSPLE) is believed to prevent metabolic syndrome. However, its efficacy has not yet been verified. Therefore, we investigated the effect of PSPLE on adipocytes. Methods. The differentiated 3T3-L1 cells used in this study were derived from preadipocytes that were differentiated into adipocytes using an adipogenic agent (insulin, dexamethasone, and 3-isobutyl-1-methylxanthine); approximately 90% of the cells were differentiated using this method. Results. Treating the differentiated 3T3-L1 cells with PSPLE caused a dose-dependent decrease in the number of adipocytes rather than preadipocytes. In addition, treatment with PSPLE resulted in apoptosis of the differentiated 3T3-L1 cells as determined by DAPI analysis and flow cytometry. PSPLE also increased the expression of cleaved caspase-3 and poly ADP-ribose polymerase (PARP). Furthermore, PSPLE induced downregulation of interleukin-6 (IL-6) and tumor necrosis factor-? (TNF-?) gene expression in the differentiated 3T3-L1 cells. Conclusions. These results suggest that PSPLE not only induced apoptosis but also downregulated inflammation-associated genes in the differentiated 3T3-L1 cells.

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/ title=”The effects of resveratrol intervention on risk markers of cardiovascular health in overweight and obese subjects: a pooled analysis of randomized controlled trials.”>
The effects of resveratrol intervention on risk markers of cardiovascular health in overweight and obese subjects: a pooled analysis of randomized controlled trials.

July 2016

Background:
Potential effects of resveratrol consumption on cardiovascular risk factors and body weight in overweight/obese adults have not been fully elucidated. Our present analysis was to evaluate the effects of resveratrol consumption on risk markers related to cardiovascular health in overweight/obese Individuals.
METHODS:
Multiple literature databases were systematically searched, and 21 studies were included. Effect sizes were expressed as weighted mean difference (WMD) and 95% confidence interval (CI), and heterogeneity was assessed with the I2 test. Publication bias and subgroup analyses were also performed.
Results:
There were variations in reporting quality of included studies. Resveratrol intervention significantly lowered total cholesterol (WMD, -0.19 mmol/L; 95% CI, -0.32 to -0.06; P = 0.004), systolic blood pressure (WMD, -2.26 mmHg; 95% CI, -4.82 to -0.49; P = 0.02), and fasting glucose (WMD, -0.22 mmol/L; 95% CI, -0.42 to -0.03; P = 0.03). Heterogeneity was noted for these outcomes (35.6%, 38.7% and 71.4%, respectively). Our subgroup analysis showed significant reductions in total cholesterol, systolic blood pressure, diastolic blood pressure, glucose, and insulin in subjects ingesting higher dose of resveratrol (?300 mg/day).
Conclusion:
Our finding provides evidence that daily resveratrol consumption might be a candidate as an adjunct to pharmacological management to better prevent and control cardiovascular in overweight/obese individuals.

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/ title=”Fucoidan, a sulfated polysaccharide, inhibits adipogenesis through the mitogen-activated protein kinase pathway in 3T3-L1 preadipocytes.”>
Fucoidan, a sulfated polysaccharide, inhibits adipogenesis through the mitogen-activated protein kinase pathway in 3T3-L1 preadipocytes.

May 2010

AIMS: Fucoidan, consisting of L-fucose together with xylose, galactose and mannose, is a sulfated polysaccharide from brown seaweeds, which has been reported to affect the development of adipocytes. However, the role of fucoidan in adipogenesis remains elusive. In the present study, we have investigated the inhibitory effects of fucoidan on adipocyte differentiation via mitogen-activated protein kinase (MAPK) signaling pathway in 3T3-L1 preadipocytes. MAIN
METHODS:
Differentiation of 3T3-L1 preadipocytes was induced in the presence or absence of fucoidan. The effects of fucoidan on adipogenic gene expression and MAPK activation were investigated. KEY FINDINGS: Fucoidan treatment inhibits adipocyte differentiation, evidenced by decreased lipid accumulation and down regulation of adipocyte markers. Fucoidan then inhibited the expression of both early CCAAT-enhancer-binding proteins alpha (C/EBPalpha) and peroxisome proliferator-activated receptors gamma (PPARgamma) and late activating protein 2 (aP2) adipogenic transcription factors, which is a crucial role for adipocyte development. Moreover, our results revealed that fucoidan inhibited the early activation of p38 MAPKs, extracellular signal-regulated kinases (ERK) and Jun N-terminal kinase (JNK). SIGNIFICANCE: Overall, these findings are a strong indication that fucoidan might inhibit adipogenesis in 3T3-L1 preadipocytes, due to inhibition of the MAPK signaling pathway that involves adipogenic transcription factors.

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/ title=”Urinary bisphenol A and obesity NHANES 2003-2006″>
Urinary bisphenol A and obesity NHANES 2003-2006

August 2011

Background:
Bisphenol A (BPA) is a chemical suspected of causing endocrine and metabolic disruption in animals and humans. In rodents, in utero exposure to low-dose BPA is associated with weight gain. Detectable levels of BPA are found in most Americans due to its widespread use in the manufacture of food and drink packaging. We hypothesized that urinary BPA concentrations would be positively associated with general and central obesity.
METHODS:
Cross-sectional analysis of urinary BPA concentrations, body mass index, and waist circumference in 2747 adults (aged 18-74), using pooled data from the 2003/04 and 2005/06 National Health and diet therapy Examination Surveys.
Results:
The creatinine-adjusted geometric mean urinary BPA concentration was 2.05?g/g creatinine (25th percentile: 1.18, 75% percentile: 3.33). Relative to those in the lowest BPA quartile, participants in the upper BPA quartiles were more likely to be classified as obese (quartile 2 odds ratio (OR): 1.85, 95% confidence interval (CI): 1.22, 2.79; quartile 3 OR: 1.60, 95% CI: 1.05-2.44; quartile 4 OR: 1.76, 95% CI: 1.06-2.94). Higher BPA concentration was also associated with abdominal obesity (quartile 2 OR: 1.62, 95% CI: 1.11, 2.36; quartile 3 OR: 1.39, 95% CI: 1.02-1.90; quartile 4 OR: 1.58, 95% CI: 1.03-2.42). CONCLUSIONS: Higher BPA exposure is associated with general and central obesity in the general adult population of the United States. Reverse causation is of concern due to the cross-sectional nature of this study; longitudinal studies are needed to clarify the direction of the association.

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/ title=”Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents.”>
Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents.

September 2012

CONTEXT: Bisphenol A (BPA), a manufactured chemical, is found in canned food, polycarbonate-bottled liquids, and other consumer products. In adults, elevated urinary BPA concentrations are associated with obesity and incident coronary artery . BPA exposure is plausibly linked to childhood obesity, but evidence is lacking to date. OBJECTIVE:
To examine associations between urinary BPA concentration and body mass outcomes in children. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional analysis of a nationally representative subsample of 2838 participants aged 6 through 19 years randomly selected for measurement of urinary BPA concentration in the 2003-2008 National Health and diet therapy Examination Surveys. MAIN OUTCOME MEASURES: Body mass index (BMI), converted to sex- and age-standardized z scores and used to classify participants as overweight (BMI?85th percentile for age/sex) or obese (BMI ?95th percentile).
Results:
Median urinary BPA concentration was 2.8 ng/mL (interquartile range, 1.5-5.6). Of the participants, 1047 (34.1% [SE, 1.5%]) were overweight and 590 (17.8% [SE, 1.3%]) were obese. Controlling for race/ethnicity, age, caregiver education, poverty to income ratio, sex, serum cotinine level, caloric intake, television watching, and urinary creatinine level, children in the lowest urinary BPA quartile had a lower estimated prevalence of obesity (10.3% [95% CI, 7.5%-13.1%]) than those in quartiles 2 (20.1% [95% CI, 14.5%-25.6%]), 3 (19.0% [95% CI, 13.7%-24.2%]), and 4 (22.3% [95% CI, 16.6%-27.9%]). Similar patterns of association were found in multivariable analyses examining the association between quartiled urinary BPA concentration and BMI z score and in analyses that examined the logarithm of urinary BPA concentration and the prevalence of obesity. Obesity was not associated with exposure to other environmental phenols commonly used in other consumer products, such as sunscreens and soaps. In stratified analysis, significant associations between urinary BPA concentrations and obesity were found among whites (P

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