Around the world over thousands of years, patients have received root-cause holistic treatment for their diseases with personalized
treatment, diet and lifestyle modification recommendations. Read the inspiring true stories of practitioners who heal people and who recovered
from their problems after allergies treatment at their clinics. Many have been generous to share their knowledge and experience for the benefit
of other holistic experts and patients alike. Many practitioners share their Case Studies and the healing powers of allergies and related therapies
as they heal people who benefited from our expertise.
Pycnogenol inhibits the release of histamine from mast cells.
January 2003
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/>Phytother Res. 2003 Jan;17(1):66-9. PMID: 12557250
Anti-allergic Inflammatory Triterpenoids Isolated from the Spikes of Prunella vulgaris.
December 2015
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/>Nat Prod Commun. 2016 Jan ;11(1):31-2. PMID: 26996013
Soothing and anti-itch effect of quercetin phytosome in human subjects: a single-blind study.
December 2015
We evaluated the ability of quercetin, a natural antioxidant formulated in a specific delivery system, to reduce skin inflammation induced by a variety of stimuli, including UV radiation, stimulation with a histamine solution, or contact with chemical irritants. In particular, we tested the soothing and anti-itch effect of Quercevita(®), 1% cream for external use, a formulation characterized by a phospholipids-based delivery system. PATIENTS AND
METHODS:
The study was a monocentric, single blind trial that enrolled a group of 30 healthy volunteers. The back of each subject was examined to identify four quadrants with no previous skin damage or naevi that were treated in order to induce a controlled and reversible form of skin stress. The areas were treated as follows: no product; Quercevita(®) 1% cream, 2 mg/cm(2); placebo; positive control (a commercially available topical formulation containing 1% dexchlorpheniramine).
Results:
Only quercetin phospholipids 1% and dexchlorpheniramine 1% achieved a significant reduction in erythema with comparable
Results:
(-10.05% [P=0.00329] for quercetin phospholipids 1% vs -14.05% [P=0.00046] for the positive control). Moreover, quercetin phospholipids 1% and dexchlorpheniramine 1% were both associated with a significant decrease in mean wheal diameter: (-13.25% and -12.23% for dexchlorpheniramine 1%, respectively). Similar findings were reported for the other tested parameters.
Conclusion:
Quercetin has a skin protective effect against damage caused by a variety of insults, including UV radiation, histamine, or contact with toxic chemical compounds. Indeed, quercetin is able to reduce redness, itching, and inflammation of damaged skin; it may also help restore skin barrier function, increasing hydration, and reducing water loss.
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/>Clin Cosmet Investig Dermatol. 2016 ;9:55-62. Epub 2016 Feb 26. PMID: 27013898
Phase II enzymes induction blocks the enhanced IgE production in B cells by diesel exhaust particles.
March 2006
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/>Appl Microbiol Biotechnol. 2006 Mar;70(2):247-53. Epub 2005 Jun 28. PMID: 16920990
trans-Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation.
December 2008
Results:
Treatment of human eosinophils with trans-resveratrol at concentrationsCONCLUSIONS AND IMPLICATIONS: trans-Resveratrol is effective at inhibiting human eosinophil activation and degranulation at concentrations
/ onclick=”MoreLine(‘11105’, ‘trans-Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation.’)”>
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/>Br J Pharmacol. 2008 Dec;155(7):995-1004. Epub 2008 Sep 8. PMID: 18776917
Procyanidin C1 from apple extracts inhibits Fc epsilon RI-mediated mast cell activation.
January 2008
Polyphenol-enriched fractions, which are extracted from unripe apples (Rosaceae, Malus spp.), consisting of procyanidins (polymers of catechins) are known to have an anti-allergenic effect on patients with various allergic s. Although it has been reported that apple extracts inhibit histamine release from mast cells, the molecular mechanisms for this anti-allergenic effect are not well understood. To elucidate the molecular mechanisms by which apple extracts induce their anti-allergenic effects, the effects of purified apple extract components on high-affinity receptors for IgE (Fc epsilon RI)-mediated mast cell activation were investigated.
METHODS:
The anti-allergic effect of oral administration of apple procyanidin extracts on passive cutaneous anaphylactic responses of BALB/c mice was assessed. We evaluated the effects of procyanidin C1 (PC1) [epicatechin-(4beta–>8)-epicatechin-(4beta–>8)-epicatechin], a component of the procyanidin fraction, on mouse bone-marrow-derived mast cell degranulation, cytokine production, protein tyrosine phosphorylation and on the generation of intracellular reactive oxygen species (ROS) of cells stimulated by Fc epsilon RI cross-linking in vitro.
Results:
In an in vivo study, oral administration of the procyanidin fraction suppressed the mast-cell-dependent allergic reaction. In in vitro studies, PC1 dose-dependently decreased Fc epsilon RI-mediated degranulation and cytokine production of mast cells. Furthermore, PC1 inhibited tyrosine phosphorylation of Syk and linker for activation of T cells, and the ROS generation in stimulated mast cells. CONCLUSIONS: PC1 suppresses Fc epsilon RI-mediated mast cell activation by inhibiting intracellular signaling pathways. These observations provide evidence for the anti-allergenic effects of the procyanidin-enriched apple extract.
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/>Int Arch Allergy Immunol. 2008;147(3):213-21. Epub 2008 Jul 2. PMID: 18594151