The aim of this study was to observe the effect of a combined pharmacologic and complementary and alternative medicine (CAM) treatment, which included biotherapeutic drainage, for a young woman with interstitial cystitis (IC).A 17-year old female patient was referred for treatment with a 2-year diagnosis of IC and dissatisfaction with her 3-month use of Elmiron. She was kept on Elmiron and prescribed additional CAM treatments, including biotherapeutic drainage, combination homeopathic medications, and asked to keep a journal. The resolution of her symptoms occurred during a 6-month period. She was followed for 2 years.After the first month of treatment, the patient’s symptoms greatly diminished. By the end of the second month, she discontinued use of Elmiron, with the exception of one acute dose in the fourth month. By the sixth month of treatment, her symptoms had resolved.A multimodal approach integrating the use of pharmacologic and CAM treatments, including biotherapeutic drainage, holds promise as an effective treatment for IC patients.