Nageen Sharma
Craniosacral therapy
Federal Hostels , Faisalabad, Punjab, Pakistan, 38000
Years of experience 3

Total years in practice: 3

Published Date
November 01, 2010
Abstract Authors
Chien-Te Li, Ching-Hsiung Lin, Te-Yu Kao, Ming-Fang Wu, Chin-Shui Yeh, Kun-Tu Yeh, Jiunn-Liang Ko
Abstract Source
Pharm Biol. 2010 Nov;48(11):1302-9. Epub 2010 Aug 25. PMID: 20738166
Abstract Affiliation
Institute of Medical and Molecular Toxicology, Chung Shan Medical University, Taichung, Taiwan.
Study Type
Cancer Care
Herbal Therapy, Holistic Medicine
Abstract Content
CONTEXT: Tianhua (TH-R) is extracted from Trichosanthes kirilowii Maxim (Cucurbitaceae) containing trichosanthin, a traditional Chinese medicine, which has been locally reported to have good anticancer effects in vivo in both animal and human models. However, there have been several reports that trichosanthin has an anticancer effect involving apoptosis. OBJECTIVE:
To investigate other anticancer effects of TH-R, various tumorigenesis parameters were verified. MATERIALS AND
Telomerase activity, anti-apoptosis, anti-migration and immunomodulatory activity were estimated by telomeric repeat amplification protocol assay (TRAP), flow cytometry, Boyden chamber assay and ELISA assay, respectively.
In our studies, we are the first to find that TH-R had a cytotoxic effect on lung cancer cells in MTS assays; it could change the cell cycle distribution of human lung cancer cells (A549 cell line) and induce apoptosis. Further anti-telomerase effects in human lung adenocarcinoma A549 cells using the TRAP assay were noted. TH-R also had an aggregation effect on peripheral blood lymphocytes, but no effect on stimulating peripheral lymphocytes to produce human interferon-?(IFN-?). TH-R could inhibit the migration, or metastatic ability, of A549 cells by Boyden chamber assay. In the oral feeding therapy of an in vivo mouse model, there was an initial inhibition of A549 cancer cell growth, but no statistical difference after one month of therapy. DISCUSSION AND
It has been proven that medicinal herbs such as Tianhua have positive effects against cancer through preventing or inhibiting the process of lung tumorigenesis.
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