Serum vitamin C and spinal pain: a nationwide study.
Total years in practice: 3
July 17, 2016
Clermont E Dionne, Danielle Laurin, Thérèse Desrosiers, Belkacem Abdous, Natalie Le Sage, Jérôme Frenette, Myrto Mondor, Sylvie Pelletier
Pain. 2016 Jul 18. Epub 2016 Jul 18. PMID: 27434504
Clermont E Dionne
Back Pain, Neck Pain
Back pain brings about one of the heaviest burden of . Despite much research, this condition remains poorly understood and effective treatments are frustratingly elusive. Thus, researchers in the field need to consider new hypotheses. Vitamin C (ascorbic acid) is an essential co-factor for collagen crosslinks, a key determinant of ligament, tendon and bone quality. Recent studies have reported high frequency of hypovitaminosis C in the general population. We hypothesized that lack of vitamin C contributes to poor collagen properties and back pain. We conducted this study to examine the associations between serum concentration of vitamin C and the prevalence of spinal pain and related functional limitations in the adult general population.This study used nationwide cross-sectional data from the U.S. National Health and diet therapy Examination Survey (NHANES) 2003-2004. Data were available for 4,742 individuals aged?20 years.Suboptimal serum vitamin C concentrations were associated with the prevalence of neck pain (adjusted odds ratio (aOR): 1.5; 95% confidence interval (CI): 1.2-2.0), low back pain (aOR: 1.3; 95% CI: 1.0-1.6), and low back pain with pain below knee (aOR: 1.3; 95% CI: 1.0-1.9) in the past three months, self-reported diagnosis of arthritis/rheumatism (aOR: 1.4; 95% CI: 1.2-1.7), and related functional limitations' score (adjusted difference of means (aB): 0.03; 95% CI: 0.00-0.05).The prevalence of hypovitaminosis C in the general population is high. Our study shows associations betweenvitamin C and spinal pain that warrant further investigation to determine the possible importance of vitamin C in the treatment of back pain patients.
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