Nageen Sharma
Craniosacral therapy
Federal Hostels , Faisalabad, Punjab, Pakistan, 38000
Years of experience 3

Total years in practice: 3

Published Date
June 19, 2016
Abstract Authors
Yi-Wen Huang, Chun-Yi Chuang, Yih-Shou Hsieh, Pei-Ni Chen, Shun-Fa Yang, Shih-Hsuan-Lin, Yang-Yu Chen, Chiao-Wen Lin, Yu-Chao Chang
Abstract Source
Environ Toxicol. 2016 Jun 20. Epub 2016 Jun 20. PMID: 27322511
Abstract Affiliation
Yi-Wen Huang
Study Type
Functional Medicine, Holistic Medicine, Naturopathic Medicine, Nutrition, Integrative Medicine, Diet Therapy
Abstract Content
Raspberries (Rubus idaeus L.) have been extensively studies worldwide because of their beneficial effects on health. Recently reports indicate that crude extracts of Rubus idaeus (RIE) have antioxidant and anticancer ability. The aim of this study was to evaluate the mechanism of its antimetastatic ability in oral cancer cells. In this study, SCC-9 and SAS oral cancer cells were subjected to a treatment with RIE and then analyzed the effect of RIE on migration and invasion. The addition of RIE inhibited the migration and invasion ability of oral cancer cells. Real time PCR, western blot and zymography analysis demonstrated that mRNA, protein expression and enzyme activity of matrix metalloproteinases-2 (MMP-2) were down-regulated by RIE. Moreover, the phosphorylation of Focal adhesion kinase (FAK), src, and extracellular signal-regulated kinase (ERK) were inhibited after RIE treatment. In conclusion, these results demonstrated that RIE exerted an inhibitory effect of migration and invasion in oral cancer cells and alter metastasis by suppression of MMP-2 expression through FAK/Scr/ERK signaling pathway.© 2016 Wiley Periodicals, Inc. Environ Toxicol, 2016.
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