Nageen Sharma
Craniosacral therapy
Federal Hostels , Faisalabad, Punjab, Pakistan, 38000
Years of experience 3

Total years in practice: 3

Published Date
December 31, 2011
Abstract Authors
Jeong Won Hwang, Jung Han Oh, Hwa-Seung Yoo, Yeon-Weol Lee, Chong-Kwan Cho, Ki-Rok Kwon, Jung-Ho Yoon, Junsoo Park, Song Her, Zee-Won Lee, Ik-Soon Jang, Jong-Soon Choi
Abstract Source
Am J Chin Med. 2012 ;40(1):187-202. PMID: 22298458
Abstract Affiliation
Jeong Won Hwang
Study Type
Therapeutic Substances
Cancer Care
Herbal Therapy, Holistic Medicine
Abstract Content
Administration of mountain ginseng (MG) extract can restore advanced cancer to a normal state. To elucidate the mechanism by which MG extract prevents the progression of lung cancer, the processes of proliferation and death of lung cancer cells (A549) were examined after treatment with MG extract. Butanol-extracted MG (BX-MG) showed a high inhibitory effect (IC(50) = 2 mg/ml) by attenuating proliferation and inducing apoptosis in lung cancer cells. By HPLC-UV analysis of BX-MG, ginsenosides, Rb1 was identified as the most abundant ginsenoside, followed by Rg1, Re, Rc and Rb2. BX-MG induced caspase-3 dependent apoptosis by inhibiting NF-?B. In addition, BX-MG activated p53 and p21, resulting in the attenuated proliferation of A549 cells. Reduced activity of the NF-?B promoter and increased activity of the p53 promoter indicate that BX-MG regulates apoptosis at the level of transcription in lung cancer cells. Furthermore, BX-MG blocked the nuclear translocation of RelA and the associated reduction in surviving. These results suggest that BX-MG inhibits lung cancer cell growth by activating tumor suppressors and inhibiting nuclear translocation of NF-?B.
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