Vaidya Rahul Gupta, B.A.M.S , M.D. (Ayurveda)
Ayurveda
Shri Vishva Prangana Ayurved Clinic & Panchakarma Center, Haldwani Mukhani Chauraha, Opposite Vivekanand Hospital, Uttrakhand, Haldwani, Uttarakhand-263139 (INDIA)
Years of experience 12

Total years in practice: 12

Published Date
August 05, 2020
Abstract Authors
Manish V. Patel, Kalapi B. Patel, and S. N. Gupta
Abstract Source
AYU: An international's quarterly journal of research in ayurveda
Abstract Affiliation
US National Library of Medicine National Institutes of Health
Study Type
Research
Therapeutic Substances
Figs
Conditions
Ulcerative Colitis
Therapies
Ayurveda
Reference
Abstract Content

Introduction

Ulcerative colitis is a chronic inflammatory bowel disease. Its incidence is more from 20 to 40 years of age and 5–10 per 100,000 persons are at risk.[] Bleeding in the stool with increased bowel frequency is the cardinal feature of this disease. Weakness is more common due to the loss of water and blood in the stool. In conventional Western medicine, some drugs like sulfasalazine may give mild relief in symptoms and signs but after some time patients need more doses of the same drug. Some patients get to benefit from steroids, which again are not suitable because of their side-effects. Even after taking steroids and sulfasalazine drugs patients suffer from the disease. So the patients are always seeking some alternative therapy promising more effective and safer outcomes.

The authors found some encouraging results in the patients of ulcerative colitis with certain Ayurvedic treatments. The treatment significantly corrected bleeding in stool and bowel frequency which are the cardinal features of ulcerative colitis, In addition, the treatments also improved the general condition of the patient. Ulcerative colitis is a disease of Purishavaha srotas. In Ayurveda, Raktatisara is mentioned as an advanced stage of Pittatisara. Piccha basti also mentioned as the management of Raktatisara in Charaka Samhita.[] This disease can be co-related with ulcerative colitis.

Aims and Objectives

The aims and objectives of this study were as follows –

  1. To prove the efficacy of Ayurvedic treatment in the management of ulcerative colitis.

  2. To provide a large population suffering from ulcerative colitis, a future possibility of safer treatment; this can be helpful in reducing the need of steroids and surgical processes.

Materials and Methods

Selection of patients

Forty-three cases with a classical picture of ulcerative colitis were randomly selected irrespective of age, sex, and chronicity from the OPD and IPD of the P. D. Patel Ayurveda Hospital, attached to J. S. Ayurveda College, Nadiad, Gujarat.

Criteria for inclusion

  • Signs and symptoms of ulcerative colitis

  • Colonoscopic diagnosis of ulcerative colitis

Criteria for exclusion

  • Patients who had undergone surgeries

  • Patients who had complications like anal fistula

  • Patients with any other associated disease

Plan of study and treatments

  • Proforma compiled with detailed clinical history and physical exam of the patients.

  • Investigations like Hb g%, Erythrocyte sedimentation rate, Stool routine - microscopy and colonoscopy

  • After confirming the diagnosis 43 patients were given the following treatment –

    • Udumbara kvatha (ingredient is Udumbar tvak-Ficus glomerata) – 40 ml/two times a day

    • Lodhra tvak churna (Symplocos racemosa) – 1 g + Musta moola churna (cyperus rotundus) – 1 g + Nagakesara (Mesua ferrea) churna – 1 g + Mukta panchamrut rasa-125 mg / three times in a day with water (the ingredients of Mukta panchamrut rasa are Mukta bhasma – 8 parts + Praval bhasma – 4 parts + Banga bhasma – 2 parts + Shankha bhasma - 1 part + Shukti bhasma – 1 part, processed in Ikshurasa, Godugdha, Vidai svarasa, Kumari svarasa, Shatavari Svarasa, Tulasi svarasa and Hansapadi svarasa).

    • Kutaja Ghana vati (ingredient is Kutaja tvak-Holarrhena antidysenterica) – 1g / three times a day.

    • Udumbara kvatha basti (ingredient is Udumbar tvak-Ficus glomerata) daily for one week and then twice a week for the next three weeks.

This treatment was given for a study period of one month.

Preparation of medicines

Medicines were prepared under expert supervision and purchased from Sunder Ayurveda Pharmacy, Nadiad.

Diet

Patients were kept on pitta –shamaka, laghu, grahi and pathya food articles.

If the patient was taking any modern medicine, doses of these were gradually reduced as the patient responded to Ayurvedic treatments.

Criteria for assessment

The improvement in the patients was assessed on the basis of relief in the symptoms and signs of the disease together with laboratory investigations. All the symptoms and signs were given grade scores and assessed before as well as after treatment. Changes in hemoglobin, ESR, and body weight were also recorded before and after treatment. Reductions in the doses of steroid and sulfasalazine drugs were also recorded.

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Observations, Results and Discussion

Most of the patients (93.02%) belonged to the 20 – 40 years age group [Table 1]. In this study 65.12% of them were males and 34.88% were females [Table 2]. In other studies of modern medicines, the incidence of this disease in males and females is equal. Of the patients, 83.72% were Hindu [Table 3]; 46.51% had less than 1 year chronicity; 20.93% patients belonged to the 1 to 3 years chronicity group; 20.93% were found in the more than 3 to 5 years chronicity group. Only 11.63% patients were found in the more than 5 years’ chronicity group [Table 4].

Table 1

Distribution of the patients according to age

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Table 2

Distribution of the patients according to sex

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Table 3

Distribution of the patients according to religion

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Table 4

Distribution of the patients according to chronicity

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Bowel frequency was reduced by 81.81% and this benefit was statistically highly significant, Bleeding in stool was reduced by 91.58% and this was also statistically highly significant, Abdominal pain was reduced by 86.76% and this too was statistically highly significant, Weakness was reduced by 65.97%, again a statistically highly significant result, Body weight was increased by 2.31% and it was also statistically highly significant [Table 5]. Hemoglobin level was increased by 16.76%, which was statistically a highly significant result, ESR was decreased by 44.16% and it was also statistically highly significant, RBC in stool was decreased by 93.02% and it too was statistically highly significant, Pus cells in stool were decreased by 80.76% and it also was statistically highly significant [Table 6]. Forty-three patients had positive occult blood test before starting this treatment. Only four patients were found with positive occult blood test after the trial therapy. So 90.70% patients showed negative occult blood test after this treatment.[Table 7]. The drug prednisolone was taken by 16 patients in this study and the dose was reduced by 87.32%, that suggests a highly significant result, The dose of the sulfasalazine drug was reduced by 77.00% and it was also statistically highly significant [Table 8]. None of the patients developed any new complication or new undesirable features [Table 9]. All the signs and symptoms, laboratory investigations and dose of steroids and sulfasalazine drugs were reduced, which was statistically highly significant.

Table 5

Effects of Ayurved therapy on signs and symptoms of ulcerative colitis

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Table 6

Effects of Ayurvedic therapy on investigations of patients of ulcerative colitis

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Table 7

Effects of Ayurvedic therapy on occult blood test

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Table 8

Effects on reduction of the dose of steroids and sulfasalazine drugs

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Table 9

Improvement in symptoms and signs and investigations

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Probable mode of action of the therapy

Ulcerative colitis is a disease of purisha vaha srotas which is caused by Pitta pradhana Vata doshas. Udumbara kvatha has properties of Pitta Vata shamana and also vrana shodana and ropana[] which help in healing ulcers in the colon by basti karma. It also has stambhana properties that help in reducing the bowel frequency and check bleeding. Kutaja ghan vati[] contains ghana satva of Kutaja tvak and has an Atisara nashaka (stambhana) guna that also helps in reducing the bowel frequency. Musta[] with its grahiaction relieves the ama in the body and also reduces the bowel frequency. Nagakeshara has Raktatisara nashaka[] and Lodhra[] has rakta stambhaka action that checks the bleeding. Mukta panchamrut rasa[] is a classical compound Ayurveda drug that relieves excessive Pitta dosha and ushna guna in body. One of the ingredients of Mukta also relieves mental stress which is a contributing factor to the disease.

Conclusion

On the basis of our clinical observation and discussion, it may be concluded that ulcerative colitis was found in middle-aged people between 20 to 40 years of age. The results obtained may be attributed to the disease-modifying effect of the trial therapy by means of its anti-pitta, vranashodhana-ropana, grahi and stambhana properties. All the signs and symptoms were reduced by more than 80% and the reduction was statistically highly significant. RBCs in stool which is the main clinical sign of this disease was reduced by 93.02%. Hemoglobin increased by 16.76%. The dose of steroids was reduced by 87.32%. All the results were statistically highly significant. The trial therapy is an ideal drug as a safe and effective alternative in case of ulcerative colitis.

Acknowledgments

The authors are thankful to the management and the Principal of J.S Ayurveda College and P.D.Patel Ayurveda Hospital, Nadiad for providing the permission and facilities for this study.

References

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2. Vaidya Jadavaji Trikamji Aacharya., editor. 2nd ed. Varanasi: Chaukhamba Sanskrit Sansthan; 1990. Agnivesha, Charaka, Dridhabala, Charaka samhita, Chikitsa Sthana, Atisara Chikitsa Adhyaya, 19/69-70 and 93-94. []
3. Dvivedi Vishvanath., editor. 9th ed. Varanasi: Motilal Banarasidas prakashan; 1998. Bhavamishra, Bhavaprakash Nighantu, Vatadi Varga / 8-9; p. 339. []
4. Ibidem (3), Bhavaprakash Nighantu, Guduchyadi varga / 111-112. p. 191.
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6. Dvivedi Vishvanath. 9th ed. Varanasi: Motilal Banarasidas Prakashan; 1998. Hindi commentator, Bhava prakash nighantu; p. 121. []
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