Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells.
Total years in practice: 3
January 15, 2008
Hye-Young Min, Eun-Jung Park, Ji-Young Hong, You-Jin Kang, Sun-Jack Kim, Hwa-Jin Chung, Eun-Rhan Woo, Tran Manh Hung, Ui Jung Youn, Yeong Shik Kim, Sam Sik Kang, KiHwan Bae, Sang Kook Lee
Bioorg Med Chem Lett. 2008 Jan 15;18(2):523-6. Epub 2007 Nov 28. PMID: 18063366
Herbal Therapy, Holistic Medicine
Dibenzocyclooctadiene lignans isolated from Schisandra chinensis showed antiproliferative effects in various human cancer cells. The methoxy groups at C-3, C-4, C-3', and C-4', the hydroxyl group at C-8', and the stereo-configuration of the biphenyl ring and the angeloyl group might have influence on these activities. Additional studies indicate that one of mechanism of action of an active compound schizantherin C in A549 human lung cancer cells was related to the inhibition of cell cycle progression in G0/G1 phase.
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