Anti-allergic Inflammatory Triterpenoids Isolated from the Spikes of Prunella vulgaris.
Total years in practice: 3
December 31, 2015
Hyun Gyu Choia, Tae Hoon Kim, Sang-Hyun Kim, Jeong Ah Kim
Nat Prod Commun. 2016 Jan ;11(1):31-2. PMID: 26996013
Hyun Gyu Choia
Functional Medicine, Naturopathic Medicine
Twelve known triterpenoids (1-12) and two steroids (13 and 14) have been isolated from the spike of the plant Prunella vulgaris. Among them, 2?,3?,23-trihydroxyursa-12,20(30)-dien-28-oic acid (10) was isolated for the first time from this plant. All isolates were evaluated for their inhibitory effect on the gene expression of tumor necrosis factor-? (TNF-?) and interleukin-6 (IL-6), and release of histamine in human mast cells. ?-Amyrin (5), 10, and euscaphic acid (12) showed suppression of histamine release with percentage inhibitions of 46.7, 57.9, and 54.2%, respectively. In addition, 5 and 10 showed strong inhibition of TNF-? and IL-6 in the test for pro-inflammatory cytokines. Our results suggest that compounds 5 and 10 largely contribute to the anti-allergic inflammatory effect of P. vulgaris.
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