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A RANDOMIZED CONTROLLED TRIAL OF GODANTI BHASMA AGAINST BALAPOSHAKA CHURNA IN MANAGEMENT OF BALASHOSHA W.S.R. TO PROTEIN ENERGY MALNUTRITION
January 2020
ABSTRACT
Title:
A Randomized Controlled
Trial Of Godanti Bhasma Against Balaposhaka Churna In Management Of Balashosha
W.S.R. To Protein Energy Malnutrition
Yogesh Shivaji Chavan1 Dr.G Jai2
Background
& Objective: Today Pediatric malnutrition
constitutes a major public health problem in India & other countries of
third world. Lots of attempts have been made to minimize this at National level
but these are not sufficient. Therefore Indigenous system of medicine
especially Ayurvediy rasasastra can play major role in providing health to
children.
Design:
A Randomized controlled trial was conducted.
Methods:
30 number of participants were selected from nearby rural Govt. UP School,
Velliyakulam (Chertala) satisfying the inclusion & exclusion criteria. They
were randomly divided in two groups. The trial drug Godanti bhasma is
administered in study group & Balaposhaka churna in control group for
duration of 1 month. Follow up taken after completion of medicine & after 3
months. Assessment based on blood values & clinical features was done
before & after the treatment. The results were statistically analyzed &
compared in between two groups.
Findings:
The
participants were in the age group of 5 to 12 years with mean age 8.89yrs. The
study included nineteen females and eleven male participants. The mean weight
was 19.40 with a S.D. of 2.28. After the
treatment weight, height, MUAC, S.Albumin was significantly increased in both
the groups.In symptomatic evaluation both drug were significantly effective,
But the trial drug was more effective on height gain, Mukha snigdhata, Netra
snigdhata & S.Albumin than
the control drug.
Conclusion:
Godanti
bhasma is effective in management of Balashosha (Protein energy malnutrition).
Key
Words: Godanti bhasma, Protein energy malnutrition,
Balaposhaka churna
1 MD(Ay) Scholar,
Dept of Rasasastra, Govt. Ayurveda College, Tripunithura, Kerala. 2 Professor, Dept
of Rasasastra, Govt. Ayurveda College, Tripunithura, Kerala.
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/>IJAPC
Concept Of Balanced Ahara In Obesity
May 2018
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/>wjpps, Volume 7, Issue 5, 1791-1796
Purple Sweet Potato Leaf Extract Induces Apoptosis and Reduces Inflammatory Adipokine Expression in 3T3-L1 Differentiated Adipocytes.
December 2014
/ onclick=”MoreLine(‘11641’, ‘Purple Sweet Potato Leaf Extract Induces Apoptosis and Reduces Inflammatory Adipokine Expression in 3T3-L1 Differentiated Adipocytes.’)”>
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/>Evid Based Complement Alternat Med. 2015 ;2015:126302. Epub 2015 Jun 11. PMID: 26170870
Fucoidan, a sulfated polysaccharide, inhibits adipogenesis through the mitogen-activated protein kinase pathway in 3T3-L1 preadipocytes.
May 2010
METHODS:
Differentiation of 3T3-L1 preadipocytes was induced in the presence or absence of fucoidan. The effects of fucoidan on adipogenic gene expression and MAPK activation were investigated. KEY FINDINGS: Fucoidan treatment inhibits adipocyte differentiation, evidenced by decreased lipid accumulation and down regulation of adipocyte markers. Fucoidan then inhibited the expression of both early CCAAT-enhancer-binding proteins alpha (C/EBPalpha) and peroxisome proliferator-activated receptors gamma (PPARgamma) and late activating protein 2 (aP2) adipogenic transcription factors, which is a crucial role for adipocyte development. Moreover, our results revealed that fucoidan inhibited the early activation of p38 MAPKs, extracellular signal-regulated kinases (ERK) and Jun N-terminal kinase (JNK). SIGNIFICANCE: Overall, these findings are a strong indication that fucoidan might inhibit adipogenesis in 3T3-L1 preadipocytes, due to inhibition of the MAPK signaling pathway that involves adipogenic transcription factors.
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/>Life Sci. 2010 May 22 ;86(21-22):791-7. Epub 2010 Mar 25. PMID: 20346961
Urinary bisphenol A and obesity NHANES 2003-2006
August 2011
Bisphenol A (BPA) is a chemical suspected of causing endocrine and metabolic disruption in animals and humans. In rodents, in utero exposure to low-dose BPA is associated with weight gain. Detectable levels of BPA are found in most Americans due to its widespread use in the manufacture of food and drink packaging. We hypothesized that urinary BPA concentrations would be positively associated with general and central obesity.
METHODS:
Cross-sectional analysis of urinary BPA concentrations, body mass index, and waist circumference in 2747 adults (aged 18-74), using pooled data from the 2003/04 and 2005/06 National Health and diet therapy Examination Surveys.
Results:
The creatinine-adjusted geometric mean urinary BPA concentration was 2.05?g/g creatinine (25th percentile: 1.18, 75% percentile: 3.33). Relative to those in the lowest BPA quartile, participants in the upper BPA quartiles were more likely to be classified as obese (quartile 2 odds ratio (OR): 1.85, 95% confidence interval (CI): 1.22, 2.79; quartile 3 OR: 1.60, 95% CI: 1.05-2.44; quartile 4 OR: 1.76, 95% CI: 1.06-2.94). Higher BPA concentration was also associated with abdominal obesity (quartile 2 OR: 1.62, 95% CI: 1.11, 2.36; quartile 3 OR: 1.39, 95% CI: 1.02-1.90; quartile 4 OR: 1.58, 95% CI: 1.03-2.42). CONCLUSIONS: Higher BPA exposure is associated with general and central obesity in the general adult population of the United States. Reverse causation is of concern due to the cross-sectional nature of this study; longitudinal studies are needed to clarify the direction of the association.
/ onclick=”MoreLine(‘10951’, ‘Urinary bisphenol A and obesity NHANES 2003-2006’)”>
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/>Environ Res. 2011 Aug ;111(6):825-30. Epub 2011 Jun 14. PMID: 21676388
Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents.
September 2012
To examine associations between urinary BPA concentration and body mass outcomes in children. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional analysis of a nationally representative subsample of 2838 participants aged 6 through 19 years randomly selected for measurement of urinary BPA concentration in the 2003-2008 National Health and diet therapy Examination Surveys. MAIN OUTCOME MEASURES: Body mass index (BMI), converted to sex- and age-standardized z scores and used to classify participants as overweight (BMI?85th percentile for age/sex) or obese (BMI ?95th percentile).
Results:
Median urinary BPA concentration was 2.8 ng/mL (interquartile range, 1.5-5.6). Of the participants, 1047 (34.1% [SE, 1.5%]) were overweight and 590 (17.8% [SE, 1.3%]) were obese. Controlling for race/ethnicity, age, caregiver education, poverty to income ratio, sex, serum cotinine level, caloric intake, television watching, and urinary creatinine level, children in the lowest urinary BPA quartile had a lower estimated prevalence of obesity (10.3% [95% CI, 7.5%-13.1%]) than those in quartiles 2 (20.1% [95% CI, 14.5%-25.6%]), 3 (19.0% [95% CI, 13.7%-24.2%]), and 4 (22.3% [95% CI, 16.6%-27.9%]). Similar patterns of association were found in multivariable analyses examining the association between quartiled urinary BPA concentration and BMI z score and in analyses that examined the logarithm of urinary BPA concentration and the prevalence of obesity. Obesity was not associated with exposure to other environmental phenols commonly used in other consumer products, such as sunscreens and soaps. In stratified analysis, significant associations between urinary BPA concentrations and obesity were found among whites (P
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/>JAMA. 2012 Sep 19 ;308(11):1113-21. PMID: 22990270