fbpixel

Hair Loss research studies for holistic treatments

Around the world over thousands of years, patients have received root-cause holistic treatment for their diseases with personalized
treatment, diet and lifestyle modification recommendations. Read the inspiring true stories of practitioners who heal people and who recovered
from their problems after hair-loss treatment at their clinics. Many have been generous to share their knowledge and experience for the benefit
of other holistic experts and patients alike. Many practitioners share their Case Studies and the healing powers of hair-loss and related therapies
as they heal people who benefited from our expertise.

/ title=”Hair loss Remedies in Ayurveda a Clinical Documentation”>
Hair loss Remedies in Ayurveda a Clinical Documentation

The present day lifestyle is more sophisticated but moving away from nature in case of food habits, pollution, stress etc. Now-a-days humans are more prone to metabolic disorders, hormonal disorders and stress related disorders of which hair fall spreads to all the categories. In Ayurveda this is called as Khalitya and has suggested classical remedies of herbs and Upacharas. While modern science claims that once the hairline goes up it never comes back and the only remedy is hair implant. We have done clinical documentation to prove the efficacy of Ayurveda treatment in Hair fall management by following a proper Pathya-Apathya and using some classical herbs internally as well as externally for the Khalitya (early age hair loss). The clinical documentation of more than 200 patients is made.


All the patients were given the same protocol of Keshya herbs and specially prepared Hair oil with Keshya herbs in the base of black sesame oil. The study was conducted for three months. Before and after treatment data was compared, which gave a statistically highly significant result. 

 

Introduction: 

 We humans consider hair as a part of beauty. Each person wants to have the right amount of hair at the right places. Less or too much hair or hairs at the wrong places pose a problem.

 

Hair loss is a common complaint in the 21st Century. There are several causes of hair loss. Most common among them are malnutrition, chronic illnesses, hormonal imbalance, unhealthy lifestyle, metabolic disorders, stress related disorders, seasonal changes, pollution, certain medications, allergies, hormonal changes during pregnancy, menopause, genetic tendencies and use of chemicals in hairs etc.

 

Excess of Pitta dosha in the body is the chief cause of hair problems. Pitta is increased by excessive intake of tea, coffee, alcohol, meats and excessive smoking. Eating too much fried, oily, greasy, spicy, sour, and acidic foods also aggravates pitta. 

 

Intake of too many chemical medicines, low blood circulation, anemia, and general weakness after different diseases, stress, anxiety, and mental tension are also prime causes of hair loss. 

 

Chronic diseases like typhoid fever, presence of dandruff or lice and hormonal imbalance also cause hair loss. Frequently, patients are faced with a number of manufacturer’s claims that their products will benefit hair loss. Keeping Khalitya’s problem in mind, the author suggested physicians of Chakrapani Ayurveda Clinic and Research Center based in Jaipur to do some work in this direction. Chakrapani Centre have been treating hair fall with the Ayurveda herbs and have been seeing positive results which paved way for documentation on hair loss intending the information to serve as the true scenario behind genuine claims of hair regrowth in pure Ayurvedic way so that healthcare providers and patients can separate some of the valid claims for hair regrowth from those that are purely fiction.

 

AIim of the Study

 The purpose of the study is to generate initial evidence of Ayurveda regimens which can then provide lead for large scale study with more precise protocols like with control group and having Prakriti based analysis of the effect of these remedies.

 

Materials and Methods

 

Selection of Patient

 34 patients of the age group between 20 years to 35 years from the OPD of Chakrapani Ayurveda Clinic and Research Center irrespective of sex, caste, religion, economical status etc. have been randomly selected for the study. Of these 25 persons have done the usual follow up and final data was compiled from the results of these 25 patients.

 

Selection of herbs

Internal Herbs:

Hair care capsule has Brahmi, Jatamansi, Bhringaraj, Guduchi, Yashtimadhu and Neem that supports the hair growth.

 

Amalaki Rasayan is a fortified (by 7 Bhavna of fresh Amalaki juice) tablet of Amalaki powder given in the dose of 2 tablets of 300 mg each thrice daily. In case of associated symptoms Ayurveda herbal remedies and lifestyle counseling are done.

 

 External Oils and Herbs:

Special Amla Oil – contains Amalaki fruit, Brahmi leaf, Ela seed, rose petal, Kapur Kachri rhizome, Bhringaraj whole plant, Musta rhizome, Japakusum flower prepared in fresh Amla juice and sesame oil.

 

Duration:

 A time period of 3 months is selected for the treatment so as to show visible positive results.

 

Dose:

 Hair care capsule 2 capsules X 3 times a day after each meal with water

 Amalaki Rasayan 2 capsules X 3 times a day after each meal with water

 


Assessment of Hair Loss and Clinical Evaluation Methods:


We have considered evaluating hair loss by means of three methods. They are:

  • 60 seconds hair fall test: For conducting this test the patient should comb the hair downwards from the vertex part to all the sides in 60 seconds time period. The fallen hair should be collected and counted.

  • Global Photography: The world wide done photographic documentation is called serial photographic documentation of hair loss. There are five photographic views taken by a high resolution digital camera from a standard distance.

  • Vertex view.

  • Mid Pattern view

  • Frontal view to reveal the hair line.

  • Temporal view (on both sides)

Hair Line Measurement: 


  • The hair line along the midline starting from between the eyebrows

  • The left oblique starting from the middle of the left eyebrow and 

  • The right oblique hair line starting from the middle of the right eyebrow; should be noted. 


Observation Results:


The results were incredible. More than 90% of people have received great results. Comparison of photographs between before and after 3 months of treatments showed very significant results.

The observations and measurements were statistically analysed using paired ‘t’ tests and probability was assessed. The observations and results are being presented as below:

Table 1

Age wise distribution of 25 patients

          

Age range

Number of Patients

%

20 – 25

06

24

26 – 30

13

52

31 – 35

04

16

35 – 40

41 – 45

02

08


Table 2

Sex wise distribution of 25 patients


Sex

Number of patients

%

Female

05

20

Male

20

80

Table 3

Effect of treatment on the measurement of MidLine of the eyebrow

B.T (Mean ±SEM)

A.T (Mean±SEM)

Difference(Mean ±SEM)

7.26±0.26

6.06±0.19

1.20±0.20

          Statistical evaluation = Paired t test N=25, t=5.679, two tailed P<0.0001. 

This shows that the results were extremely significant.


Table 4

Effect of treatment on the measurement of Right Oblique of the right middle of the eyebrow


B.T (Mean ±SEM)

A.T (Mean±SEM)

Difference (Mean±SEM)

8.96±0.48

7.28±0.45

1.68±0.28

          Statistical evaluation = Paired t test N=25, t=5.956, two tailed  P<0.0001 

This shows that the results were extremely significant. 

Table 5

Effect of treatment on the measurement of Left Oblique of the right middle of the eyebrow


B.T (Mean ±SEM)

A.T (Mean±SEM)

Difference(Mean±SEM)

8.75±0.45

7.18±0.42

1.56±0.27


Statistical evaluation = Paired t test N=25, t=5.758, two tailed  P<0.0001 

This shows that the results were extremely significant. 

Table 6

Comparison of treatment on the number of Hair fall in 60 second


B.T (Mean ±SEM)

A.T (Mean±SEM)

Difference (Mean±SEM)

23.8±4.438

10.24 ± 2.17

13.56±3.34


Statistical evaluation = Paired t test N=25, t=4.054, two tailed P<0.0005 

This shows that the results were very highly significant. 


Discussion


This study is a beginning. On the basis of the positive observations, we have started a large scale study on more number of patients, with more precise criteria, considerations of Prakriti of patients and having a control group. We have observed that in addition to regimens, correction of food habits and lifestyle also plays an important role.


Conclusion


The effort was to look for evidence of good effect on hair growth by the Ayurveda regimen. The study is giving a lead for a large scale research on this line so that firm evidence can be acquired. The significance of this study is its non invasive nature of treatment. Moreover, it is quite economical and not costly for the end user. It is usually said that the Ayurveda regimen does have great results on different health issues but the World always asks us about the evidence. So, we thought of generating evidence. It seems that our study was able to go to the right goal.

/ onclick=”MoreLine(‘26331’, ‘Hair loss Remedies in Ayurveda a Clinical Documentation’)”>
…more

/ title=”Combination of topical garlic gel and betamethasone valerate cream in the treatment of localized alopecia areata: a double-blind randomized controlled study.”>
Combination of topical garlic gel and betamethasone valerate cream in the treatment of localized alopecia areata: a double-blind randomized controlled study.

January 2007

Background:
Alopecia areata is a recurrent, nonscarring type of hair loss. Different modalities of treatment have been used to induce hair re-growth. AIMS: To determine the efficacy of topical garlic gel in the treatment of alopecia areata.
METHODS:
Patients were randomly divided into two groups of garlic gel and placebo. The two groups were advised to follow the treatment twice daily, for three months. Both groups received topical application of corticosteroid (betamethasone cream 0.1% in isopropyl alcohol) twice daily. Baseline demographic characteristics and the size of patches, total number of grown hair and number of terminal hair at the end of each month were recorded. Effectiveness was assessed by scoring the results. Statistical analysis was done by means of chi-square and t test.
Results:
Forty patients met the inclusion criteria and enrolled for the study. The first group (garlic treated) consisted of 20 patients (12 males, 60% and eight females, 40%). The second group (control) consisted of 20 patients (10 males, 50% and 10 females, 50%). At the end of the treatment, good and moderate responses were observed in 19 (95%) and one (5%) patients of the case group respectively, which was significantly better than the control group (P = 0.001). No complication was observed in the patients under study.
Conclusion:
The present study showed that the use of garlic gel significantly added to the therapeutic efficacy of topical betamethasone valerate in alopecia areata and that it can be an effective adjunctive topical therapy for alopecia areata.







/ onclick=”MoreLine(‘11112’, ‘Combination of topical garlic gel and betamethasone valerate cream in the treatment of localized alopecia areata: a double-blind randomized controlled study.’)”>
…more

/ title=”Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5?-Dihydrotestosterone-Treated Human Dermal Papilla Cells.”>
Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5?-Dihydrotestosterone-Treated Human Dermal Papilla Cells.

May 2016

Background:
Dihydrotestosterone (DHT) induces androgenic alopecia by shortening the hair follicle growth phase, resulting in hair loss. We previously demonstrated how changes in the microRNA (miRNA) expression profile influenced DHT-mediated cell death, cell cycle arrest, cell viability, the generation of reactive oxygen species (ROS), and senescence. Protective effects against DHT have not, however, been elucidated at the genome level. OBJECTIVE:
We showed that epigallocatechin gallate (EGCG), a major component of green tea, protects DHT-induced cell death by regulating the cellular miRNA expression profile.
METHODS:
We used a miRNA microarray to identify miRNA expression levels in human dermal papilla cells (DPCs). We investigated whether the miRNA expression influenced the protective effects of EGCG against DHT-induced cell death, growth arrest, intracellular ROS levels, and senescence.
Results:
EGCG protected against the effects of DHT by altering the miRNA expression profile in human DPCs. In addition, EGCG attenuated DHT-mediated cell death and growth arrest and decreased intracellular ROS levels and senescence. A bioinformatics analysis elucidated the relationship between the altered miRNA expression and EGCG-mediated protective effects against DHT.
Conclusion:
Overall, our results suggest that EGCG ameliorates the negative effects of DHT by altering the miRNA expression profile in human DPCs.








/ onclick=”MoreLine(‘11111’, ‘Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5?-Dihydrotestosterone-Treated Human Dermal Papilla Cells.’)”>
…more

/ title=”Hair loss associated with paroxetine treatment: a case report.”>
Hair loss associated with paroxetine treatment: a case report.

July 1999

Alopecia and hair loss are rare side effects of psychotropic drugs. There are a few case reports on hair loss associated with tricyclic antidepressants and serotonin selective reuptake inhibitors (SSRIs), but none deal specifically with paroxetine. We report on a 37-year-old female who complained of moderate hair loss during paroxetine treatment. Findings on discontinuation and rechallenge supported the assumption that the hair loss was a side effect of the paroxetine. Further investigation is needed to determine the scope of this troubling side effect.

/ onclick=”MoreLine(‘9380’, ‘Hair loss associated with paroxetine treatment: a case report.’)”>
…more

/ title=”Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study.”>
Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study.

February 2010

Background:
We have previously reported that several selective protein kinase C (PKC) inhibitors, including procyanidin B-2, promote hair epithelial cell growth and stimulate anagen induction. OBJECTIVES:
We discuss the hypothesis that the hair-growing activity of procyanidin B-2 is related to its downregulation or inhibition of translocation of PKC isozymes in hair epithelial cells.
METHODS:
We examined the effect of procyanidin B-2 on the expression of PKC isozymes in cultured murine hair epithelial cells as well as PKC isozyme localization in murine dorsal skin at different stages in the hair cycle.
Results:
We observed that procyanidin B-2 reduces the expression of PKC-alpha, -betaI, -betaII and -eta in cultured murine hair epithelial cells and also inhibits the translocation of these isozymes to the particulate fraction of hair epithelial cells. Our immunohistochemical analyses demonstrated that PKC-alpha, -betaI, -betaII and -eta are specifically expressed in the outer root sheaths of both anagen and telogen hair follicles. The hair matrix at the anagen stage showed no positive staining for these PKC isozymes. Moderate to intense staining for PKC-betaI and -betaII in the epidermis and hair follicles was observed in a telogen-specific manner; however, expression of PKC-alpha and -eta during the telogen stage was not conspicuous. Gö 6976, an inhibitor of calcium-dependent (conventional) PKC, proved to promote hair epithelial cell growth. CONCLUSIONS: These results suggest that PKC isozymes, especially PKC-betaI and -betaII, play an important role in hair cycle progression and that the hair-growing mechanisms of procyanidin B-2 are at least partially related to its downregulation of PKC isozymes or its inhibition of translocation of PKC isozymes to the particulate fraction of hair epithelial cells.






/ onclick=”MoreLine(‘8390’, ‘Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study.’)”>
…more

/ title=”Onion juice (Allium cepa L.), a new topical treatment for alopecia areata.”>
Onion juice (Allium cepa L.), a new topical treatment for alopecia areata.

June 2002

Alopecia areata is a patchy, non-scarring hair loss condition. Any hair-bearing surface may be involved, and different modalities of treatment have been used to induce hair regrowth. This study was designed to test the effectiveness of topical crude onion juice in the treatment of patchy alopecia areata in comparison with tap water. The patients were divided into two groups. The first group [onion juice treated] consisted of 23 patients, 16 males (69.5%) and 7 females (30.5%). Their ages ranged between 5-42 years with a mean of 22.7 years. The second group [control; tap-water-treated] consisted of 15 patients, 8 males (53.3%) and 7 females (46.6%). Their ages ranged between 3-35 years with a mean of 18.3 years. The two groups were advised to apply the treatment twice daily for two months. Re-growth of terminal coarse hairs started after two weeks of treatment with crude onion juice. At four weeks, hair re-growth was seen in 17 patients (73.9%), and, at six weeks, the hair re-growth was observed in 20 patients (86.9%) and was significantly higher among males (93.7%) compared to females (71.4%) P<0.0001. In the tap-water treated-control group, hair re-growth was apparent in only 2 patients (13%) at 8 weeks of treatment with no sex difference. The present study showed that the use of crude onion juice gave significantly higher results with regard to hair re-growth than did tap water (P<0.0001), and that it can be an effective topical therapy for patchy alopecia areata.

/ onclick=”MoreLine(‘8389’, ‘Onion juice (Allium cepa L.), a new topical treatment for alopecia areata.’)”>
…more

Have a Question?